Table 2.

Summary of LTA Discovery Analyses for Loci with SNP-Trait Association p Values < 5 × 10⁻⁸

SNP ID	Allele	Chr	Position	In Gene	Closest Gene	Genes in LD Block	Beta	SE	p Value
LTA DBP
rs13306561	a	1	11,788,391	MTHFR	MTHFR	NPPA-AS1, CLCN6, MTHFR, NPPA	0.48	0.07	2.08 × 10−10
rs2004776	t	1	228,915,325	AGT	AGT	AGT	0.35	0.06	3.20 × 10−8
rs7599598a	a	2	96,715,567	FER1L5	FER1L5	FER1L5	−0.31	0.05	2.91 × 10−8
rs198823	t	6	26,230,912	NA	HIST1H2BC	HIST1H1T, HIST1H4A, HIST1H2BB, HIST1H3C, HIST1H3A, HIST1H2BC, TRIM38, HFE, HIST1H2AB, HIST1H2AC, HIST1H3B, HIST1H4B, HIST1H4C, HIST1H1A, HIST1H1C	−0.33	0.06	6.57 × 10−9
rs12258967	c	10	18,767,965	CACNB2	CACNB2	CACNB2	0.35	0.06	2.48 × 10−9
rs12244842	t	10	63,109,192	C10orf107	C10orf107	C10orf107	−0.38	0.06	7.05 × 10−9
rs2681472	a	12	88,533,090	ATP2B1	ATP2B1	ATP2B1, LOC338758	0.52	0.07	4.01 × 10−13
rs3184504	t	12	110,368,991	SH2B3	SH2B3	TRAFD1, PTPN11, RPL6, ALDH2, ATXN2, TMEM116, ERP29, MAPKAPK5, ADAM1, SH2B3, C12orf51, C12orf47, NAA25, ACAD10, BRAP	0.39	0.05	6.08 × 10−13
rs1133323	t	15	72,999,278	NA	COX5A	CSK, CPLX3, COX5A, SCAMP2, C15orf17, MPI, ULK3, LMAN1L, MIR4513	−0.33	0.05	2.66 × 10−9
rs6092743	a	20	57,133,765	NA	C20orf174	NA	0.50	0.08	1.11 × 10−8
LTA SBP
rs880315	t	1	10,719,453	CASZ1	CASZ1	MTOR, C1orf127, TARDBP, EXOSC10, C1orf187, FBXO2, FBXO6, MAD2L2, MTHFR, FBXO44, SRM, PTCHD2, MASP2, UBIAD1, CASZ1, ANGPTL7, AGTRAP	−0.71	0.10	7.98 × 10−12
rs13306561	a	1	11,788,391	MTHFR	MTHFR	NPPB, NPPA-AS1, CLCN6, MTHFR, NPPA	0.88	0.12	6.38 × 10−12
rs1275988a	t	2	26,767,868	NA	KCNK3	KCNK3	−0.60	0.09	2.61 × 10−10
rs6712094	a	2	164,751,706	NA	GRB14	NA	0.60	0.10	9.89 × 10−9
rs7733331	t	5	32,864,603	NA	C5orf23	NPR3	−0.55	0.09	5.38 × 10−9
rs12705390	a	7	106,198,013	NA	PIK3CG	NA	0.63	0.11	3.17 × 10−8
rs12258967	c	10	18,767,965	CACNB2	CACNB2	CACNB2	0.63	0.10	4.53 × 10−10
rs7070797	a	10	63,221,779	NA	C10orf107	C10orf107	−0.74	0.13	4.30 × 10−8
rs2681472	a	12	88,533,090	ATP2B1	ATP2B1	ATP2B1, LOC338758	0.95	0.12	1.04 × 10−14
rs4766578	a	12	110,388,754	ATXN2	ATXN2	TRAFD1, PTPN11, RPL6, ALDH2, ATXN2, TMEM116, ERP29, MAPKAPK5, ADAM1, SH2B3, C12orf51, C12orf47, NAA25, ACAD10, BRAP	−0.56	0.09	2.82 × 10−9
rs35444	a	12	114,036,820	NA	TBX3	NA	0.55	0.09	1.47 × 10−8
rs11072518	t	15	73,021,663	NA	COX5A	CSK, CPLX3, COX5A, SCAMP2, C15orf17, CYP1A2, MPI, ULK3, LMAN1L, MIR4513	0.57	0.09	6.54 × 10−9
rs6092743	a	20	57,133,765	NA	C20orf174	NA	0.84	0.14	2.25 × 10−8
LTA MAP
rs880315	t	1	10,719,453	CASZ1	CASZ1	CASZ1	−0.46	0.07	5.49 × 10−11
rs13306561	a	1	11,788,391	MTHFR	MTHFR	NPPB, NPPA-AS1, CLCN6, MTHFR, NPPA	0.61	0.08	1.83 × 10−12
rs2004776	t	1	228,915,325	AGT	AGT	AGT	0.42	0.07	1.18 × 10−8
rs1275988a	t	2	26,767,868	NA	KCNK3	KCNK3	−0.39	0.06	1.51 × 10−9
rs12258967	c	10	18,767,965	CACNB2	CACNB2	CACNB2	0.45	0.07	4.98 × 10−11
rs2166122	t	10	63,193,080	C10orf107	C10orf107	C10orf107	−0.48	0.08	1.88 × 10−9
rs2681472	a	12	88,533,090	ATP2B1	ATP2B1	ATP2B1, LOC338758	0.69	0.08	1.77 × 10−16
rs3184504	t	12	110,368,991	SH2B3	SH2B3	CUX2, FAM109A, TRAFD1, PTPN11, RPL6, ALDH2, ATXN2, TMEM116, ERP29, MAPKAPK5, ADAM1, SH2B3, C12orf51, C12orf47, NAA25, ACAD10, BRAP	0.45	0.06	1.68 × 10−12
rs35444	a	12	114,036,820	NA	TBX3	NA	0.36	0.06	3.20 × 10−8
rs11072518	t	15	73,021,663	NA	COX5A	CSK, CPLX3, COX5A, SCAMP2, C15orf17, CYP1A2, MPI, ULK3, LMAN1L, MIR4513	0.43	0.06	8.95 × 10−11
rs6092743	a	20	57,133,765	NA	C20orf174	NA	0.64	0.10	3.60 × 10−10
LTA PP
rs880315	t	1	10,719,453	CASZ1	CASZ1	CASZ1	−0.42	0.07	5.45 × 10−9
rs7650227	t	3	41,769,941	ULK4	ULK4	ULK4	0.50	0.08	2.84 × 10−9
rs10948071a	t	6	43,388,691	NA	CRIP3	CRIP3, SLC22A7, ZNF318	−0.38	0.07	9.06 × 10−9
rs2949837a	a	7	45,960,903	NA	IGFBP3	NA	0.40	0.07	2.94 × 10−8
rs12705390	a	7	106,198,013	NA	PIK3CG	NA	0.59	0.08	5.40 × 10−14

Abbreviations are as follows: Chr, chromosome; DBP, diastolic blood pressure; LTA, long-term average; MAP, mean arterial pressure; NA, not available; PP, pulse pressure; and SBP, systolic blood pressure.

^aBP-associated loci found in our LTA analyses.