Table 4.
Trait | SNP ID | Closest Gene |
GBPG Consortium V1 BP Association Results |
PUUMA V1 BP Association Results |
Meta-analysis of GBPG Consortium and PUUMA V1 BP Association Results |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | p Value | Beta | SE | p Value | Beta | SE | p Value | |||
V1 DBP | rs7599598 | FER1L5 | −0.04 | 0.08 | 6.14 × 10−1 | 0.001 | 0.21 | 9.95 × 10−1 | −0.03 | 0.07 | 6.40 × 10−1 |
V1 SBP | rs1275988a | KCNK3 | −0.26 | 0.12 | 2.98 × 10−2 | −0.79 | 0.39 | 4.54 × 10−2 | −0.30 | 0.11 | 7.93 × 10−3 |
V1 MAP | rs1275988a | KCNK3 | −0.16 | 0.08 | 5.68 × 10−2 | −0.72 | 0.27 | 7.85 × 10−3 | −0.21 | 0.08 | 9.08 × 10−3 |
V1 PP | rs10948071a | CRIP3 | −0.24 | 0.09 | 6.69 × 10−3 | −0.25 | 0.27 | 3.56 × 10−1 | −0.24 | 0.08 | 4.17 × 10−3 |
V1 PP | rs2949837 | IGFBP3 | 0.15 | 0.09 | 9.96 × 10−2 | 0.34 | 0.26 | 1.94 × 10−1 | 0.17 | 0.09 | 4.68 × 10−2 |
Abbreviations are as follows: BP, blood pressure; DBP, diastolic blood pressure; GBPG, Global Blood Pressure Genetics; MAP, mean arterial pressure; PP, pulse pressure; PUUMA, Peking University – University of Michigan Study of Atherosclerosis; SBP, systolic blood pressure; and V1, visit 1.
Loci meeting a Bonferroni-corrected replication threshold.