Table 5.
The LTA Lead SNPs Were Investigated in the V1 Analysis of the Same Cohorts and Study Participants
| SNP ID | Allele | Chr | Position | Closest Gene |
LTA BP Results in Discovery Samples |
V1 BP Results in LTA Discovery Samples |
LTA-V1 Differences |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trait | Beta | SE | p Value | Trait | Beta | SE | p Value | Δ Beta | Δ p Value | |||||
| rs880315 | t | 1 | 10,719,453 | CASZ1 | LTA SBP | −0.71 | 0.10 | 7.98 × 10−12 | V1 SBP | −0.68 | 0.11 | 7.20 × 10−9 | 3.05 × 10−2 | −7.19 × 10−9 |
| rs13306561 | a | 1 | 11,788,391 | MTHFR | LTA SBP | 0.88 | 0.12 | 6.38 × 10−12 | V1 SBP | 0.76 | 0.14 | 1.11 × 10−7 | −1.21 × 10−1 | −1.11 × 10−7 |
| rs1275988 | t | 2 | 26,767,868 | KCNK3 | LTA SBP | −0.60 | 0.09 | 2.61 × 10−10 | V1 SBP | −0.47 | 0.10 | 1.38 × 10−5 | 1.33 × 10−1 | −1.38 × 10−5 |
| rs6712094 | a | 2 | 164,751,706 | GRB14 | LTA SBP | 0.60 | 0.10 | 9.89 × 10−9 | V1 SBP | 0.58 | 0.11 | 5.22 × 10−7 | −1.49 × 10−2 | −5.12 × 10−7 |
| rs7733331 | t | 5 | 32,864,603 | C5orf23 | LTA SBP | −0.55 | 0.09 | 5.38 × 10−9 | V1 SBP | −0.41 | 0.10 | 1.41 × 10−4 | 1.46 × 10−1 | −1.41 × 10−4 |
| rs12705390 | a | 7 | 106,198,013 | PIK3CG | LTA SBP | 0.63 | 0.11 | 3.17 × 10−8 | V1 SBP | 0.54 | 0.12 | 2.63 × 10−5 | −8.91 × 10−2 | −2.62 × 10−5 |
| rs12258967 | c | 10 | 18,767,965 | CACNB2 | LTA SBP | 0.63 | 0.10 | 4.53 × 10−10 | V1 SBP | 0.64 | 0.11 | 1.53 × 10−8 | 1.04 × 10−2 | −1.48 × 10−8 |
| rs7070797 | a | 10 | 63,221,779 | C10orf107 | LTA SBP | −0.74 | 0.13 | 4.30 × 10−8 | V1 SBP | −0.73 | 0.14 | 1.17 × 10−6 | 1.58 × 10−2 | −1.12 × 10−6 |
| rs2681472 | a | 12 | 88,533,090 | ATP2B1 | LTA SBP | 0.95 | 0.12 | 1.04 × 10−14 | V1 SBP | 0.93 | 0.13 | 1.69 × 10−11 | −1.65 × 10−2 | −1.69 × 10−11 |
| rs4766578 | a | 12 | 110,388,754 | ATXN2 | LTA SBP | −0.56 | 0.09 | 2.82 × 10−9 | V1 SBP | −0.65 | 0.10 | 1.18 × 10−9 | −9.01 × 10−2 | 1.64 × 10−9 |
| rs35444 | a | 12 | 114,036,820 | TBX3 | LTA SBP | 0.55 | 0.09 | 1.47 × 10−8 | V1 SBP | 0.51 | 0.11 | 2.63 × 10−6 | −3.03 × 10−2 | −2.61 × 10−6 |
| rs11072518 | t | 15 | 73,021,663 | COX5A | LTA SBP | 0.57 | 0.09 | 6.54 × 10−9 | V1 SBP | 0.73 | 0.11 | 2.93 × 10−11 | 1.61 × 10−1 | 6.52 × 10−9 |
| rs6092743 | a | 20 | 57,133,765 | C20orf174 | LTA SBP | 0.84 | 0.14 | 2.25 × 10−8 | V1 SBP | 1.01 | 0.16 | 2.18 × 10−9 | 1.66 × 10−1 | 2.03 × 10−8 |
| rs13306561 | a | 1 | 11,788,391 | MTHFR | LTA DBP | 0.48 | 0.07 | 2.08 × 10−10 | V1 DBP | 0.48 | 0.09 | 1.28 × 10−7 | 2.50 × 10−3 | −1.28 × 10−7 |
| rs2004776 | t | 1 | 228,915,325 | AGT | LTA DBP | 0.35 | 0.06 | 3.20 × 10−8 | V1 DBP | 0.44 | 0.07 | 1.53 × 10−8 | 8.31 × 10−2 | 1.67 × 10−8 |
| rs7599598 | a | 2 | 96,715,567 | FER1L5 | LTA DBP | −0.31 | 0.05 | 2.91 × 10−8 | V1 DBP | −0.37 | 0.07 | 6.54 × 10−8 | −5.75 × 10−2 | −3.63 × 10−8 |
| rs198823 | t | 6 | 26,230,912 | HFE | LTA DBP | −0.33 | 0.06 | 6.57 × 10−9 | V1 DBP | −0.32 | 0.07 | 4.52 × 10−6 | 1.51 × 10−2 | −4.51 × 10−6 |
| rs12258967 | c | 10 | 18,767,965 | CACNB2 | LTA DBP | 0.35 | 0.06 | 2.48 × 10−9 | V1 DBP | 0.43 | 0.07 | 3.71 × 10−9 | 7.05 × 10−2 | −1.23 × 10−9 |
| rs12244842 | t | 10 | 63,109,192 | C10orf107 | LTA DBP | −0.38 | 0.06 | 7.05 × 10−9 | V1 DBP | −0.43 | 0.08 | 6.15 × 10−8 | −4.89 × 10−2 | −5.45 × 10−8 |
| rs2681472 | a | 12 | 88,533,090 | ATP2B1 | LTA DBP | 0.52 | 0.07 | 4.01 × 10−13 | V1 DBP | 0.58 | 0.09 | 8.68 × 10−11 | 5.52 × 10−2 | −8.64 × 10−11 |
| rs3184504 | t | 12 | 110,368,991 | SH2B3 | LTA DBP | 0.39 | 0.05 | 6.08 × 10−13 | V1 DBP | 0.39 | 0.07 | 1.26 × 10−8 | −7.50 × 10−3 | −1.26 × 10−8 |
| rs1133323 | t | 15 | 72,999,278 | COX5A | LTA DBP | −0.33 | 0.05 | 2.66 × 10−9 | V1 DBP | −0.42 | 0.07 | 4.89 × 10−10 | −9.57 × 10−2 | 2.17 × 10−9 |
| rs6092743 | a | 20 | 57,133,765 | C20orf174 | LTA DBP | 0.50 | 0.08 | 1.11 × 10−8 | V1 DBP | 0.71 | 0.10 | 3.37 × 10−11 | 2.04 × 10−1 | 1.11 × 10−8 |
| rs880315 | t | 1 | 10,719,453 | CASZ1 | LTA MAP | −0.46 | 0.07 | 5.49 × 10−11 | V1 MAP | −0.43 | 0.08 | 1.47 × 10−7 | 2.86 × 10−2 | −1.47 × 10−7 |
| rs13306561 | a | 1 | 11,788,391 | MTHFR | LTA MAP | 0.61 | 0.08 | 1.83 × 10−12 | V1 MAP | 0.57 | 0.10 | 1.48 × 10−8 | −3.94 × 10−2 | −1.48 × 10−8 |
| rs2004776 | t | 1 | 228,915,325 | AGT | LTA MAP | 0.42 | 0.07 | 1.18 × 10−8 | V1 MAP | 0.51 | 0.08 | 2.45 × 10−9 | 8.91 × 10−2 | 9.33 × 10−9 |
| rs1275988 | t | 2 | 26,767,868 | KCNK3 | LTA MAP | −0.39 | 0.06 | 1.51 × 10−9 | V1 MAP | −0.34 | 0.07 | 7.06 × 10−6 | 4.63 × 10−2 | −7.06 × 10−6 |
| rs12258967 | c | 10 | 18,767,965 | CACNB2 | LTA MAP | 0.45 | 0.07 | 4.98 × 10−11 | V1 MAP | 0.50 | 0.08 | 5.57 × 10−10 | 4.52 × 10−2 | −5.07 × 10−10 |
| rs2166122 | t | 10 | 63,193,080 | C10orf107 | LTA MAP | −0.48 | 0.08 | 1.88 × 10−9 | V1 MAP | −0.50 | 0.09 | 4.76 × 10−8 | −2.38 × 10−2 | −4.57 × 10−8 |
| rs2681472 | a | 12 | 88,533,090 | ATP2B1 | LTA MAP | 0.69 | 0.08 | 1.77 × 10−16 | V1 MAP | 0.70 | 0.09 | 1.70 × 10−12 | 9.17 × 10−3 | −1.70 × 10−12 |
| rs3184504 | t | 12 | 110,368,991 | SH2B3 | LTA MAP | 0.45 | 0.06 | 1.68 × 10−12 | V1 MAP | 0.47 | 0.07 | 3.71 × 10−10 | 2.50 × 10−2 | −3.69 × 10−10 |
| rs35444 | a | 12 | 114,036,820 | TBX3 | LTA MAP | 0.36 | 0.06 | 3.20 × 10−8 | V1 MAP | 0.38 | 0.08 | 8.38 × 10−7 | 2.16 × 10−2 | −8.06 × 10−7 |
| rs11072518 | t | 15 | 73,021,663 | COX5A | LTA MAP | 0.43 | 0.06 | 8.95 × 10−11 | V1 MAP | 0.55 | 0.07 | 1.86 × 10−12 | 1.15 × 10−1 | 8.76 × 10−11 |
| rs6092743 | a | 20 | 57,133,765 | C20orf174 | LTA MAP | 0.64 | 0.10 | 3.60 × 10−10 | V1 MAP | 0.81 | 0.11 | 1.12 × 10−11 | 1.69 × 10−1 | 3.49 × 10−10 |
| rs880315 | t | 1 | 10,719,453 | CASZ1 | LTA PP | −0.42 | 0.07 | 5.45 × 10−9 | V1 PP | −0.38 | 0.08 | 3.31 × 10−6 | 4.46 × 10−2 | −3.31 × 10−6 |
| rs7650227 | t | 3 | 41,769,941 | ULK4 | LTA PP | 0.50 | 0.08 | 2.84 × 10−9 | V1 PP | 0.43 | 0.09 | 4.38 × 10−6 | −6.71 × 10−2 | −4.38 × 10−6 |
| rs10948071 | t | 6 | 43,388,691 | CRIP3 | LTA PP | −0.38 | 0.07 | 9.06 × 10−9 | V1 PP | −0.29 | 0.07 | 1.11 × 10−4 | 9.49 × 10−2 | −1.11 × 10−4 |
| rs2949837 | a | 7 | 45,960,903 | IGFBP3 | LTA PP | 0.40 | 0.07 | 2.94 × 10−8 | V1 PP | 0.36 | 0.08 | 6.88 × 10−6 | −3.79 × 10−2 | −6.85 × 10−6 |
| rs12705390 | a | 7 | 106,198,013 | PIK3CG | LTA PP | 0.59 | 0.08 | 5.40 × 10−14 | V1 PP | 0.43 | 0.09 | 1.20 × 10−6 | −1.59 × 10−1 | −1.20 × 10−6 |
Abbreviations are as follows: BP, blood pressure; Chr, chromosome; DBP, diastolic blood pressure; MAP, mean arterial pressure; LTA, long-term average; PP, pulse pressure; SBP, systolic blood pressure; and V1, visit 1.