Figure 4.

Examples of FHSSRs

Two FHSRRs (indicated by the blue shade) and the genomic landscape around them (which includes putative targets) as depicted by the UCSC Genome Browser. The tracks represent (top to bottom) base position, RefSeq genes, Broad ChromHMM (RRs), Primate Chain/Net alignment, Placental Chain/Net alignment, and RepeatMasker. Color coding for Broad ChromHMM is as follows: yellow, weak enhancer; orange, strong enhancer; red, promoter; light red, weak promoter; purple, poised promoter; and blue, insulator.

(A) SRGAP1, a gene whose expression in humans is shifted from that in other primates.

(B) HTR2C, encoding a serotonin receptor involved in several mental illnesses.