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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Neuron. 2010 Jul 29;67(2):294–307. doi: 10.1016/j.neuron.2010.06.017

Figure 6. Thalamic stimulation produced a biphasic modulation of corticostriatal EPSPs.

Figure 6

(A) Corticostriatal EPSPs recorded from a D2 MSN (inset: Experimental configuration). (B) When a thalamic stimulus train was given 25 ms before the cortical EPSPs, cortical EPSPs were depressed. (C) Cortical EPSPs before and after conditioning were superimposed to illustrate the changes in first EPSP amplitude and EPSP summation (Δt=25 ms). (D) Pooled data (n = 9) showing the effect of thalamic pre-pulse on EPSPs summation evoked by 50 Hz cortical afferent stimulation (Δt=25 ms). (E) The reduction in first EPSP amplitude was blocked by the muscarinic receptor antagonist, scopolamine. (F) When the interval between thalamic pre-pulse and cortical stimulation was prolonged to 1 s, the thalamic pre-pulse had no significant effect on first EPSP amplitude, whereas the amplitude of the 5th EPSP was significantly increased (Δt=1 s). (G) Pooled data (n = 9) showing that 1 s after thalamic pre-pulse EPSPs summation evoked by 50 Hz cortical afferent stimulation was significantly increased. (H) There was no reduction in first EPSP amplitude (Δt=1 s). Scopolamine did not significantly change the first EPSP amplitude. Experiments were performed at 32-35°C.