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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Neuron. 2010 Jul 29;67(2):294–307. doi: 10.1016/j.neuron.2010.06.017

Figure 7. Summation of corticostriatal EPSPs was increased by slowing their decay rate.

Figure 7

(A) EPSPs were fitted with five double-exponential functions (thick line). (B) Each individual fit EPSP was generated and plotted based on fitted values. (C, D) The first and fifth fitted EPSP were superimposed (C) and normalized (D) to compare amplitude and kinetics of each individual EPSP. (E) Box-plot summary of fit EPSP rise time constant. There are no significant changes in rise time constant when thalamic pre-pulse was introduced. (F) Box-plot summary of fit EPSP decay time constant. Cortical EPSP decay time constant significantly increased when the thalamic pre-pulse was given one second before cortical stimulation, but not immediate before cortical stimulation. (G) Summary graph of normalized fit EPSP amplitude plot against stimulation pulse number. Reduction in the first EPSP amplitude was only seen inΔt=25 ms (median= 80% of control, P<0.05;Wilcoxon; n=9). The amplitudes of the fit EPSPs at the longer delay (Δt=1 s) were not different from those of the control (P>0.05;Wilcoxon; n=9; in all panels: blue,Δt=25 ms; red,Δt=1 s). Experiments were performed at 32-35°C.