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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Neuron. 2010 Jul 29;67(2):294–307. doi: 10.1016/j.neuron.2010.06.017

Figure 8. Presynaptic and postsynaptic modulation was dependent on muscarinic receptor activation.

Figure 8

(A) Left: Box-plot summary of changes in first EPSP amplitude recorded from D1 MSNs with thalamic pre-pulse (Δt=25 ms; median 82% of control; P<0.05; Wilcoxon; n=8;Δt=1 s; 93.4 of control; P>0.05; Wilcoxon; n=8). Right: Pooled data showing the effect of thalamic pre-pulse on EPSPs summation in D1 MSNs evoked by 50 Hz cortical stimulation. The normalized fifth EPSP was 78 ±9% in control;Δt=25 ms; 69±8%; P>0.05; Wilcoxon; n=8;Δt=1 s, 79±8 %; P>0.05; Wilcoxon; n=8. (B) Left: Box-plot summary of changes in first EPSP amplitude in D2R neurons with thalamic pre-pulse in the presence of scopolamine (Δt=25 ms; median 104.9% of control; P>0.05; Wilcoxon; n=7;Δt=1 s, 92.1% of control; P>0.05; Wilcoxon; n=7). Right: Pooled data showing the effect of thalamic pre-pulse on EPSPs summation in D2 MSNs evoked by 50 Hz cortical stimulation in the presence of scopolamine. The normalized fifth EPSP was 137±14% in control;Δt=25 ms; 145±23%; P>0.05; Wilcoxon; n=7;Δt=1 s, 143±31%;P>0.05; Wilcoxon; n=7). (C) Left: Box-plot summary of changes in first EPSP amplitude in D2 MSNs with thalamic pre-pulse in M1 muscarinic receptor knockout mice (Δt=25 ms; 88% of control; P<0.05; Wilcoxon; n=7;Δt=1 s, 108% of control; P>0.05; Wilcoxon; n=7). Right: Pooled data showing the effect of thalamic pre-pulse on EPSPs summation in M1 knockout D2 MSNs. (The normalized fifth EPSP was 94±9% in M1 knockout control;Δt=25 ms; 101±9%; P>0.05; Wilcoxon; n=7;Δt=1 s, 92±10%; P>0.05; Wilcoxon; n=7). Experiments were performed at 32-35°C.