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Dorsal anterior cingulate (dACC), glutamate + glutamine (Glx)/creatine (Cr), baseline (pre-drug), and at week 12 (post-drug) for study completers. (A) Box plot of median Glx/Cr in the dACC at baseline and week 12. (B) Line plot of individual Glx/Cr in the dACC at baseline and week 12. Asterisk indicates significant t-statistic at p < 0.05.
