Table 1.
Study Completers: Behavioral and Clinical Measures.
| Characteristic | Baseline (Pre-drug) | Week 12 (Post-drug) | t-value | p-value |
|---|---|---|---|---|
| SMOKING BEHAVIOR | ||||
| CO* | 19.27 ± 8.48 | 4.36 ± 5.70 | 6.71 | <0.001 |
| CPD | 23.60 ± 9.20 | 2 ± 4.4 | 9.01 | <0.001 |
| STROOP TASK BEHAVIOR | ||||
| Congruent RT | 799 ± 14 | 762 ± 9 | 2.36 | 0.04 |
| Incongruent RT | 956 ± 17 | 918 ± 13 | 1.73 | 0.12 |
| Stroop effect RT | 154 ± 8 | 158 ± 6 | −0.29 | 0.78 |
| Task errors | 4.36 ± 2.94 | 11.27 ± 18.00 | −1.24 | 0.24 |
| CLINICAL MEASURES** | ||||
| FTND | 5.89 ± 2.0 | – | – | – |
| MNWS | 9.22 ± 5.61 | 6.00 ± 6.67 | 1.04 | 0.33 |
| QSU-brief | 39.11 ± 15.37 | 11.89 ± 3.52 | 4.54 | 0.002 |
| SPSRQ | 14.44 ± 5.92 | 16.44 ± 7.59 | −1.73 | 0.12 |
| CESD | 9.67 ± 4.24 | 9.33 ± 4.64 | 0.23 | 0.83 |
| SSE | 45.44 ± 12.07 | 38.67 ± 8.02 | 1.64 | 0.14 |
CESD, Center for Epidemiological Studies on Depression; CO, carbon monoxide; CPD, cigarettes per day; FTND, Fagerström Test for Nicotine Addiction; MNWS, Minnesota Nicotine Withdrawal Scale (Hughes-Hatsukami Withdrawal Scale); RT, reaction time in milliseconds; SPSRQ, Sensitivity to Punishment and Sensitivity to Reward Questionnaire; SSE, Symptoms and Side Effects; QSU-brief Questionnaire of Smoking Urges Short Form.
FTND week 12 scores have been omitted. Two of the seven items on the FTND are related to recent smoking behavior. Because subjects are enrolled in a study to reduce smoking behavior, reduced scores on this measure may reflect behavioral changes and not nicotine dependence per se.
scores imputed for two participants.
scores missing for two participants.