Table 2.

Glutamate Measurement in Dorsal Anterior Cingulate Cortex.

Metabolite	Baseline completers	Week 12 completers	t-value	p-value
Glx/Cr	0.705 ± 0.089	0.646 ± 0.045	2.743	0.023
CRLB ± SD	7.1 ± 1.7%	6.9 ± 1.5%
(CRLB Range)	(5.8–11.6%)	(5.4–10.2%)

Cr, creatine; CRLB, Cramer-Rao Lower Bounds; Glx, glutamate + glutamine.

There were no significant differences in the raw amplitude of Cr between baseline (pre-drug) and week 12 (post-drug) t₍₉₎ = −0.889, p = 0.397. There were no significant differences between baseline to week 12 in metabolite peak line width, CRLBs, gray matter voxel content, or white matter voxel content.