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Effect of L-NAME on conversion of [14C]AA to HETEs, DHTs, and EETs. Microsomes from control rats and rats treated with L-NAME and/or 2% NaCl were incubated with [14C]AA in the presence of NADPH and indomethacin. Values are mean ± SEM obtained from renal microsomes prepared from 5 rats. CYP enzyme activity in rats treated with L-NAME was 0.36 ± 0.06 nmol/mg protein per 30 minutes. *P < 0.05 vs. control.
