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Activation of the proximal hGH promoter in Pit-1– and CBP-sufficient GH3 cells after stimulation by hGHRH or PKA. GH3 cells were transfected with 195 bp of the proximal hGH promoter or mutation of the proximal GH1 and/or distal GH2 Pit-1 binding sites with (a) cotransfection of hGHRH receptor and stimulation with hGHRH(1-29)-NH2 for 6 hours, or with BSA as a control; or (b) cotransfection with WT or mutant PKA catalytic subunit. Data are expressed as relative light units (RLU) ± SEM.
