Table 3. Profile of dopamine and serotonin metabolites in the mouse striatum at day 5 postinfection with Toxoplasma GT1 strain.
DA | DOPAC | HVA | 3-MT | 5-HT | 5-HIAA | HVA/DA | HVA/3-MT | |
---|---|---|---|---|---|---|---|---|
Control | 1110+461 | 543+50 | 190+8.7 | 211+11 | 305+23 | 80+3.5 | 0.173+0.008 | 0.924+0.05 |
Infection | 1539+88 | 672+48 | 226+11 | 287+14 | 368+21 | 100+6.8 | 0.150+0.006 | 0.792+0.02 |
P value2 | <0.001 | 0.036 | 0.008 | <0.001 | 0.029 | 0.006 | 0.009 | 0.007 |
% Change3 | 38% | 24% | 19% | 36% | 20% | 25% | -14% | -15% |
Expressed as nanograms per microgram protein, mean + S.E.M.;
Derived from a one-tailed Student's t-test;
Percentage change from controls. Control: n = 19; Infection: n = 20