Extended model for NAD-ME with high PEP-CK activity. Transport modules, consisting of one or more transporters, are shown together with the net transport through the module. Abbreviations: (1) Phosphoenolpyruvate carboxylase; (2) malate dehydrogenase; (3) NAD-dependent malic enzyme (NAD-ME); (4) pyruvate dehydrogenase kinase; (5) alanine aminotransferase; (6) pyruvate, phosphate dikinase; (7) aspartate aminotransferase; (8) aspartate oxidase and aspartate kinase; (9) phosphoenolpyruvate carboxykinase (PEP-CK); 3-PGA, 3-phosphoglyceric acid; TP, triose-phosphate; CBB, Calvin–Benson–Bassham cycle; OAA, oxaloacetic acid; RE, reducing equivalent; BASS2, pyruvate transporter; NHD, sodium proton antiporter; PPT, phosphoenolpyruvate phosphate translocator; TPT, triose-phosphate phosphate translocator; ETC, electron transfer chain. Dashed arrows represent leakage to general metabolism. (This figure is available in colour at JXB online.)