Table 1.
Baseline characteristic | Entire cohort (N = 1846) | By category of baseline pre-dialysis SBP (mmHg) |
|||||
---|---|---|---|---|---|---|---|
<120 (N = 116) | 120-139 (N = 427) | 140-159 (N = 658) | 160-179 (N = 444) | ≥180 (N = 199) | P-trenda | ||
Age, years, mean (s.d.) | 57.6 (14.0) | 58.6 (14.8) | 56.5 (15.1) | 57.7 (14.1) | 57.7 (13.6) | 59.1 (11.8) | 0.19 |
Female sex (%) | 56.2 | 44.8 | 54.8 | 56.4 | 56.5 | 64.8 | < 0.01 |
Black race (%) | 62.7 | 51.3 | 62.3 | 64.9 | 62.4 | 63.8 | 0.08 |
On antihypertensive medication (%) | 79.1 | 55.9 | 67.5 | 82.8 | 86.3 | 89.5 | < 0.01 |
Current smoker (%) | 17.3 | 15.5 | 19.2 | 16.4 | 16.7 | 19.1 | 0.49 |
Cause of ESRD (%) | |||||||
Diabetic nephropathy | 37.2 | 20.7 | 25.1 | 37.7 | 43.7 | 56.3 | |
Hypertension | 31.7 | 33.6 | 37.7 | 32.1 | 27.9 | 25.6 | < 0.01 |
Glomerular disease | 13.8 | 17.2 | 26.5 | 14.0 | 13.7 | 6.5 | |
Other or unknown | 17.3 | 28.5 | 21.6 | 16.3 | 14.6 | 11.6 | |
Diabetes (%) | 44.6 | 27.6 | 33.5 | 45.9 | 48.7 | 64.3 | < 0.01 |
Modified ICED score (%) | |||||||
0–1 | 35.6 | 35.3 | 39.1 | 36.6 | 34.2 | 27.6 | |
2 | 31.3 | 29.3 | 28.3 | 32.4 | 34.2 | 28.6 | 0.03b |
3 | 33.2 | 35.3 | 32.6 | 31.0 | 31.5 | 43.7 | |
BMI, mean (s.d.) | 25.5 (5.3) | 24.8 (5.4) | 25.3 (5.0) | 25.6 (5.3) | 25.4 (5.0) | 26.1 (5.9) | 0.08 |
Vintage, years, median (IQR) | 2.2 (0.9–4.7) | 2.6 (1.4–6.4) | 2.3 (0.9–5.0) | 2.1 (0.9–4.6) | 2.2 (0.9–4.2) | 2.0 (1.0–4.0) | < 0.01 |
Mean baseline serum albumin, g per 100ml, mean (s.d.) | 3.6 (0.4) | 3.6 (0.3) | 3.6 (0.4) | 3.6 (0.4) | 3.6 (0.4) | 3.6 (0.4) | 0.66 |
Baseline serum total cholesterol, mg per 100ml, mean (s.d.) | 172.6 (40.7) | 164.8 (35.7) | 168.5 (40.3) | 176.3 (42.1) | 172.9 (40.3) | 173.1 (39.3) | 0.05 |
Residual kidney function >0 (%) | 32.9 | 23.3 | 29.0 | 37.2 | 32.2 | 34.2 | 0.03 |
Mean baseline spKt/V, mean (s.d.) | 1.6 (0.2) | 1.6 (0.2) | 1.6 (0.2) | 1.6 (0.2) | 1.6 (0.2) | 1.6 (0.2) | 0.24 |
Abbreviations: BMI, body mass index; ESRD, end-stage renal disease; HEMO study, haemodialysis study; ICED, index of coexistent diseases, modified to exclude diabetes; IQR, interquartile range; SBP, systolic blood pressure; spKt/V, single-pool Kt/Vure^_
P-value for trend across the categories of baseline SBP calculated using one-sided Cochran-Armitage trend test or linear regression as appropriate.
P-value is from χ2-test.