Table 2.
Multivariable-adjusted Model-TV-Lag analysis of all-cause mortality
| Predictor variable | Cox regression coefficient | Relative risk of all-cause mortality | P-value | |
|---|---|---|---|---|
| Pre-dialysis SBP (mmHg) | HR | 95% CI | ||
| <120 | 0.60±0.12 | 1.84 | 1.45–2.30 | <0.0001 |
| 120–139 | 0.33 ±0.11 | 1.39 | 1.12–1.70 | 0.003 |
| 140–159 | Ref. | 1.00 | Ref. | - |
| 160–179 | 0.01 ±0.12 | 1.01 | 0.80–1.28 | 0.93 |
| ≥180 | 0.07±0.28 | 1.07 | 0.83–1.39 | 0.59 |
| Age (per 10-year increment) | 0.31± 0.04 | 1.36 | 1.27–1.46 | < 0.0001 |
| Female sex | –0.11 ±0.08 | 0.89 | 0.76–1.05 | 0.16 |
| Black race | –0.35 ±0.09 | 0.70 | 0.59–0.85 | 0.0002 |
| Diabetes | 0.17± 0.08 | 1.19 | 1.01–1.40 | 0.04 |
| Dialysis vintage (per 1-year increment) | 0.02± 0.01 | 1.02 | 1.00–1.40 | 0.15 |
| Serum albumin (per 0.1 g per 100 ml increment) | –0.13± 0.01 | 0.88 | 0.86–0.89 | < 0.0001 |
| Modified ICED (per 1-unit increment) | 0.51± 0.06 | 1.66 | 1.48–1.86 | < 0.0001 |
| Residual kidney function (per 1mlmin-1 per 351) | –0.10± 0.09 | 0.90 | 0.76–1.08 | 0.27 |
| High-dose dialysis intervention group | –0.01± 0.08 | 0.99 | 0.85–1.15 | 0.88 |
| High-flux membrane intervention group | –0.11± 0.08 | 0.89 | 0.76–1.04 | 0.14 |
Abbreviations: CI, confidence interval; HR, hazard ratio; ICED, Index of Coexistent Diseases score, modified to exclude diabetes; Model-TV-Lag, SBP as time-varying variable+3-month lag; ref., referent group; SBP, systolic blood pressure. Plus-minus values are ± s.e.