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. 2014 Jun 6;42(Web Server issue):W449–W460. doi: 10.1093/nar/gku476

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — LCB search interface. Two textboxes are available to insert lists of up and down regulated genes. The search interface provides a link to the Enrichr software. Clicking this button passes the input gene lists to Enrichr for independent enrichment analysis in a new web page. The Example button fills the textboxes with sample lists. The Aggravate/Reverse slider swaps the up list with the down list so that the search is done in reverse mode. The result panel displays the top 50 matching experiments in a table where only 10 entries are displayed per page. The screenshot is from Case Study 1: searching for perturbations that could potentially reverse breast cancer progression and recurrence given a pre-compiled list of 374 breast cancer prognosis biomarker genes.