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. 2014 May 14;42(Web Server issue):W314–W319. doi: 10.1093/nar/gku411

Figure 2.

Figure 2.

Result page for DUET prediction. The results display the predicted change in folding free energy upon mutation (ΔΔG in kcal/mol). A positive value (and red writing) corresponds to a mutation predicted as destabilizing; while a negative sign (and blue writing) corresponds to a mutation predicted as stabilizing. The information displayed include the mCSM (i) and SDM (ii) individually predicted protein stability changes, the combined DUET prediction (iii), a structural summary of the mutation highlighting the wild-type residue and position number, the mutation and its 3D environment (iv). The protein and mutation can also be visualized (v), or a PDB file of the mutant downloaded for viewing in your preferred molecular visualization software.