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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Curr Opin Hematol. 2012 May;19(3):156–162. doi: 10.1097/MOH.0b013e328351c48b

Figure 1. Transcriptional regulation of MFRN1.

Figure 1

In early erythropoiesis, GATA-2 binds to two GATA-sites (−37.5 kb and −20.4 kb) in the MFRN1 distal transcriptional enhancer, but does not activate gene transcription (top panel). As erythroblasts mature, GATA-1 becomes expressed and the GATA-1/FOG-1 complex displaces GATA-2 from both DNA-binding sites in the MFRN1 distal enhancer (bottom panel) and triggers MFRN1 transcription. Reprinted with permission from J.D. Amigo et al. (ref. 9) and The American Society of Microbiology.