Table 2.
Comparison of serum PBDE, PCB, and OH-PBDE concentrations between the first and second cohorts of second trimester pregnant women recruited from San Francisco General Hospital, San Francisco, California
| Chemical analyte | 2008–2009 (n=25) | 2011–2012 (n=36)a | pc | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDL | % > MDL | GM (GSD)b | 50th % | 95th % | MDL | % > MDL | GM (GSD)b | 50th % | 95th % | ||
| PBDEs (ng/g lipid) | |||||||||||
| BDE-28 | 0.66 | 100 | 2.32 (1.68) | 2.40 | 6.97 | 0.77 | 78 | 1.38 (1.96) | 1.49 | 4.11 | 0.002 |
| BDE-47 | 11.7 | 100 | 43.1 (1.70) | 42.1 | 123.2 | 5.85 | 100 | 25.75 (2.03) | 21.8 | 102.2 | 0.002 |
| BDE-99 | 3.63 | 100 | 11.5 (1.82) | 9.80 | 27.2 | 4.92 | 61 | 6.68 (2.08) | 5.89 | 36.00 | 0.001 |
| BDE-100 | 0.91 | 100 | 9.00 (1.86) | 8.96 | 23.3 | 1.08 | 97 | 4.66 (2.21) | 4.24 | 19.84 | 0.001 |
| BDE-153 | 0.93 | 100 | 15.5 (1.82) | 16.5 | 38.3 | 1.54 | 97 | 10.87 (2.17) | 11.7 | 37.91 | 0.08 |
| ΣPBDEs | 85.8 (1.59) | 82.9 | 192.8 | 51.9 (1.92) | 47.9 | 189.4 | 0.001 | ||||
| PCBs (ng/g lipid) | |||||||||||
| PCB-74 | 0.63 | 76 | 0.89 (0.1) | 0.94 | 1.75 | 0.77 | 53 | 0.7 (2.07) | 0.81 | 1.79 | 0.23 |
| PCB-118 | 0.69 | 88 | 1.66 (0.12) | 1.82 | 3.79 | 0.92 | 100 | 1.54 (1.81) | 1.52 | 3.32 | 0.28 |
| PCB-138 | 1.63 | 64 | 2.38 (0.13) | 2.52 | 6.40 | 0.77 | 100 | 2.17 (1.82) | 1.82 | 6.05 | 0.59 |
| PCB-153 | 1.52 | 80 | 3.51 (0.15) | 3.84 | 13.56 | 0.77 | 100 | 3.53 (2.03) | 3.12 | 11.84 | 0.66 |
| PCB-180 | 1.44 | 92 | 3.19 (0.14) | 3.05 | 10.00 | 0.92 | 86 | 2.02 (2.14) | 1.95 | 6.32 | 0.02 |
| ΣPCBs | 12.3 (1.77) | 13.3 | 34.1 | 10.4 (1.86) | 9.75 | 26.8 | 0.18 | ||||
| OH-PBDEs (ng/ml) | |||||||||||
| 5-OH-BDE47 | 0.012 | 83 | 0.028 (3.52) | 0.036 | 0.131 | 0.002 | 64 | 0.004 (4.25) | 0.007 | 0.028 | <0.0001 |
| 6-OH-BDE47 | 0.010 | 92 | 0.025 (2.40) | 0.023 | 0.147 | 0.002 | 61 | 0.004 (3.43) | 0.007 | 0.021 | <0.0001 |
| 4′-OH-BDE49 | 0.010 | 50 | 0.008 (2.01) | 0.010 | 0.020 | 0.002 | 6 | -- | <MDL | 0.008 | <0.0001 |
| ΣOH-PBDEs | 0.072 (2.20) | 0.069 | 0.268 | 0.010 (3.05) | 0.014 | 0.051 | <0.0001 | ||||
| OH-PCBs (ng/ml) | |||||||||||
| 4′-OH-CB107 | 0.010 | 8 | -- | <MDL | 0.025 | 0.005 | 25 | -- | <MDL | 0.026 | -- |
| 4′-OH-CB146 | 0.006 | 13 | -- | <MDL | 0.007 | 0.005 | 47 | -- | <MDL | 0.053 | -- |
| 4′-OH-CB187 | 0.014 | 34 | -- | <MDL | 0.026 | 0.005 | 44 | -- | <MDL | 0.024 | -- |
| ΣOH-PCBs | 0.019 (1.72) | 0.019 | 0.055 | 0.017 (2.44) | 0.017 | 0.080 | 0.43 | ||||
Abbreviations: MDL = method detection limit; GM = geometric mean; GSD = geometric standard deviation.
a
OH-PBDE and OH-PCB concentrations were missing for 1 participant in the second cohort
b
GM and GSD only calculated for chemicals with detection frequencies ≥ 50 percent.
c
Differences in median chemical concentrations by cohort evaluated by Wilcoxon Rank Sum test.