Figure 5. Molecular details of the emetine–ribosome interaction.
(A) Overview of emetine at the binding interface formed by the three conserved rRNA helices and uS11. h23 is in green, h24 in cyan, h45 in blue, uS11 in pink, and emetine in yellow. (B) 2D representation showing the interaction of emetine with binding residues. Substitution contour represents potential space for chemical modification of emetine. (C) Residues in physical contact with emetine. Hydrogen bond is indicated as dashes.
Figure 5—figure supplement 1. Comparison of the emetine binding residues between Pf80S and human ribosomes.
Human and Pf-specific elements are colored in yellow and cyan respectively, with Pf numbering. Emetine is in purple.