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Neuronal acquisition/loss of cholesterol. Cholesterol synthesized by astrocytes is packaged in lipoproteins containing ApoE, released from the cell and taken up by neurons via the lipoprotein receptor-related protein 1 (LRP1)-mediated endocytosis. Cholesterol can be removed by conversion to 24S-hydroxycholesterol, a compound that can cross the BBB, by the action of cholesterol 24-hydroxylase.
