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. 2014 Jul 8;5:165. doi: 10.3389/fphar.2014.00165

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Copyright © 2014 Ali-Rahmani, Schengrund and Connor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total brain cholesterol content of mice expressing WT- or H67D-HFE. Brains were dissected from mice at 6, 12, 18, and 24 months. After homogenization, protein concentration was determined by Bradford assay (n = 7–17 per group including both male and female mice). Lipids were extracted from 100 μl of brain homogenate. Cholesterol content was measured by following the manufacturer’s protocol (Biovision), and is shown as μg of cholesterol per mg of protein (***p < 0.001). Data were analyzed using a two-way ANOVA followed by Bonferroni tests to compare effects of age and genotype on age-related changes in brain cholesterol of HFE variant mice using Graphpad (Prism) software. Error bars represent the standard error of the mean.

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