Pumps |
SR Ca2+ ATPase, fast-twitch |
Serca1 |
1.0 ± 0.65 |
n.s. |
1.1 ± 0.20 |
n.s. |
SR Ca2+ ATPase, slow-twitch |
Serca2 |
1.2 ± 0.19 |
n.s. |
13.2 ± 6.75 |
< 0.05 |
Ca2+ ATPase 1, plasma membrane |
Pmca1/Atp2b1 |
1.1 ± 0.20 |
n.s. |
33.3 ± 7.77 |
< 0.05 |
Ca2+ ATPase 4, plasma membrane |
Pmca4/Atp2b4 |
1.1 ± 0.38 |
n.s. |
30.0 ± 15.40 |
< 0.05 |
Na+/Ca2+ exchanger, plasma membrane |
Ncx/Scl8a1 |
1.4 ± 0.34 |
n.s. |
15.8 ± 6.68 |
< 0.05 |
|
Regulatory proteins |
SR, regulates SERCA2 |
Phospholamban |
2.7 ± 0.42 |
< 0.05 |
74.7 ± 10.72 |
< 0.05 |
SR, regulates SERCA1 |
Sarcolipin |
1.3 ± 0.16 |
< 0.05 |
20.6 ± 11.12 |
< 0.05 |
cytosol, regulates SERCAs |
Regucalcin |
1.5 ± 0.33 |
< 0.05 |
12.7 ± 6.3 |
< 0.05 |
|
SR calcium binding proteins |
SR, calcium binding protein, skeletal |
Calsequestrin 1 |
0.9 ± 0.26 |
n.s. |
1.5 ± 0.39 |
n.s. |
SR, calcium binding protein, cardiac |
Calsequestrin 2 |
1.5 ± 0.27 |
< 0.05 |
29.9 ± 18.30 |
< 0.05 |
SR, calcium binding protein |
Sarcalumenin |
1.4 ± 0.31 |
n.s. |
2.6 ± 0.55 |
n.s. |
|
Cytosolic calcium binding proteins |
cytosol, calcium binding protein |
Parvalbumin |
2.0 ± 0.35 |
< 0.05 |
2.3 ± 0.54 |
n.s. |
cytosol, calcium binding protein |
S100a1 |
2.3 ± 0.39 |
< 0.05 |
5.4 ± 0.68 |
< 0.05 |
calcium binding protein |
Calmodulin |
0.9 ± 0.10 |
n.s. |
10.1 ± 3.64 |
< 0.05 |
calcium binding protein, slow-twitch/cardiac |
Troponin C 1 |
1.0 ± 0.14 |
n.s. |
5.1 ± 0.59 |
< 0.05 |
calcium binding protein, fast-twitch |
Troponin C 2 |
1.4 ± 0.29 |
n.s. |
2.1 ± 0.49 |
n.s. |
|
Calcium channels |
calcium channel subunit |
Cacna1s |
1.5 ± 0.22 |
< 0.05 |
0.9 ± 0.12 |
n.s. |
calcium release channel, skeletal |
Ryanodine Receptor 1 |
1.3 ± 0.25 |
n.s. |
1.0 ± 0.16 |
n.s. |