Figure 4. Effect of diet, genotype, and haplotype on mitochondrial function.
Mitochondrial respiration and respiratory control ratio (RCR) was measured for mice fed the control and atherogenic diets: WT C57, WT C3H, MNX C57, and MNX C3H. State 3 (A) and state 4 (B) respiration were measured and the respiratory control ratio (RCR, C) was determined. Succinate was used as the oxidizable substrate. Results are expressed as mean ± SE, n=4–8 for the three parameters measured. *p<0.05 or **p<0.0001, compared to corresponding control diet counterpart. ANOVA results are provided in Supplemental Table 1 and p values for pair-wise comparisons are provided in Supplemental Table 3.
