Figure 5.

Effects of paroxetine on insulin secretion (A), intracellular insulin level (B) and intracellular 5-HT level (C) in INS-1 cells. Effects of pravastatin on insulin secretion (D) and the reversing effect of paroxetine on the stimulatory effect of 10 μmol/L pravastatin on insulin secretion in INS-1 cells (E). Effects of paroxetine on the levels of Insulin-2 and Tph-1 mRNA in INS-1cells (F). Data represent the mean±SEM of 3–4. ^bP<0.05, ^cP<0.01 vs control with 2.8 mmol/L glucose; ^eP<0.05, ^fP<0.01 vs control with 11.1 mmol/L glucose. ^hP<0.05, ⁱP<0.01 vs the Insulin-2 mRNA levels of that without paroxetine. ^kP<0.05, ^lP<0.01 vs the Tph-1 mRNA levels of that without paroxetine.