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Effects of 5-HT on the insulin secretion (A) and intracellular 5-HT level (B) in INS-1 cells. Effects of tropisetron on 5-HT-induced and paroxetine-induced inhibition of insulin secretion of INS-1 cells (C). Data represent the mean±SEM of 3–4. bP<0.05, cP<0.01 vs control with 11.1 mmol/L glucose. eP<0.05 vs 5-HT 100 μmol/L without tropisetron.
