Table 2. Physiological and biochemical characteristics in CON, HFD, and DM rats. Data represent the mean±SEM of 6–7 rats. cP<0.01 vs CON rats. eP<0.05, fP<0.01 vs HFD rats.
| Parameter | CON | HFD | DM |
|---|---|---|---|
| Initial body weight (g) | 110.33±3.32 | 110.33±2.65 | 109.50±1.65 |
| Final body weight (g) | 388.83±3.64 | 355.33±17.24 | 308.75±7.81ce |
| Serum glucose (mmol/L) | 7.29±0.18 | 7.36±0.24 | 24.29±1.19cf |
| Serum triglyceride (mmol/L) | 1.73±0.10 | 2.06±0.12c | 2.48±0.22ce |
| Serum total cholesterol (mmol/L) | 1.85±0.12 | 2.83±0.19c | 5.11±0.43cf |
| Serum insulin (mIU/L) | 42.47±4.45 | 46.50±4.12 | 44.91±6.90 |
| HOMA-IR | 13.33±1.38 | 15.07±1.53 | 47.40±5.65cf |
| AUC of serum glucose in OGTT (mmol·h/L) | 13.81±0.29 | 16.28±0.31 | 52.39±1.27cf |
| AUC of serum insulin in OGTT (mIU·h/L) | 123.02±8.78 | 141.81±13.63 | 132.83±14.74 |
Glucose was measured by a glucose test kit (Jiancheng Biotech, Nanjing, China). Insulin was measured by iodine [125I]insulin radioimmunoassay kit (BNIBT Co, Beijing, China). Total cholesterol and triglyceride were measured by test kits (BHKT Clinical Reagent Co, Beijing, China).