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. 2014 May 26;35(6):738–751. doi: 10.1038/aps.2014.23

Figure 3.

Figure 3

Effects of SKF83959 on the passive membrane properties of the hippocampal pyramidal neuron in simulations. (A) Membrane potential responses of the hippocampal pyramidal neuron to a −50 pA, 300 ms pulse for control and SKF83959 treated cells with (gray trace) or without compensating membrane potential to the control level (top) as described in the Materials and methods. (B) Effects of SKF83959 on the sag ratio with membrane potential compensation measured as described in the methods. (C) Effects of SKF83959 on the input resistance. (D) Effects of SKF83959 on the membrane potential. Ctrl, control; SKF_all, overall effects of SKF83959 without membrane potential compensation; SKF_all_comp, overall effects of SKF83959 with membrane potential compensation; SKF_na, modifying Na+ channels alone; SKF_kdr, modifying kdr channels alone; SKF_h, modifying HCN channels alone.