Figure 5.

Effects of SKF83959 on dendritic excitability in the hippocampal pyramidal neuron in simulations. Voltage responses were recorded at the soma and at an apical dendrite 210 μm from the soma simultaneously during direct injection at this dendrite of a series of currents of different amplitudes, without membrane potential compensation. (A) Example traces show voltage responses of the soma (left) and dendrite (right) to a pulse of 550 pA for 500 ms. Spike numbers were detected under a series of current stimuli from 475 pA to 725 pA with steps of 25 pA, at the dendrite (B) and at the soma (C). Dendritic spike threshold (D) and rheobase current (E) were examined as described in the methods. SKF_all, SKF_na, SKF_kdr, and SKF_h are the same as in Figure 4.