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. 2014 May 26;35(6):738–751. doi: 10.1038/aps.2014.23

Figure 6.

Figure 6

Effects of SKF83959 on depolarization block in the hippocampal pyramidal neuron in simulations and experiments. Depolarization block was examined as described in the methods with the membrane potential compensated to control levels. (A) In simulations, voltage responses at the soma with (bottom) or without (up) the overall effect of SKF83959 under 0.59 nA current injection. (B) The minimal currents required to induce depolarization block under different conditions in simulations. (C) Experimental results showing voltage responses at the soma from experiments with (bottom) or without (up) SKF83959 (50 μmol/L) treatment during 800 pA current injection in simulations. (D) Experimental results showing the minimal currents required to induce depolarization block with or without SKF83959 (50 μmol/L) treatment (n=7). SKF_all, SKF_na, SKF_kdr and SKF_h are the same as in Figure 4. Ctrl, control; SKF, SKF83959 (50 μmol/L) treatment. cP<0.01 vs control, paired t-test.