Figure 8.
Effects of SKF83959 on synapse-driven firing in simulations of hippocampal pyramidal neurons. Five independent synapses (with Gmax_AMPA set to 0.021 μS) were randomly placed on the apical dendritic compartments 150–400 μm from the soma and randomly (Poisson) activated at different average frequencies (EPSP frequencies). (A) Example traces showing the voltage response at the soma to average EPSP frequencies of 20 Hz (left) and 40 Hz (right) without membrane potential compensation. (B) The firing frequencies in response to a series of average EPSP frequencies, from 10 Hz to 40 Hz, under either control or SKF83959 treated conditions, without membrane potential compensation. SKF_all, SKF_na, SKF_kdr, and SKF_h are the same as in Figure 4.