Table 1.

Phenotypes of BACE1 and BACE2 knockout mice

	Putative substrate	References
BACE1 knockout mouse phenotypes
Astrogenesis increase, neurogenesis decrease	JAG1	Hu et al (2013)44
Axon guidance defects	CHL1	Rajapaksha et al (2011),34 Cao et al (2012),35 Hitt et al (2012)36
Hyperactivity	NRG1	Dominguez et al (2005),27 Savonenko et al (2008)46
Hypomyelination	NRG1	Willem et al (2006),37 Hu et al (2006),38 Hu et al (2008)39
Memory deficits	Unknown	Laird et al (2005),19 Ohno et al (2004),28 Ohno et al (2007),30 Ohno et al (2006),41 Kobayashi et al (2008)40
Insulin sensitivity enhanced	Unknown	Dominguez et al (2005),27 Meakin et al (2012),49 Hoffmeister et al (2013)50
Muscle spindle reduction	NRG1	Cheret et al (2013)42
Neurochemical deficits	Unknown	Harrison et al (2003)43
Neurodegeneration with age	Unknown	Hu et al (2010)45
Postnatal lethality, growth retardation	Unknown	Dominguez et al (2005)27
Retinal abnormalities	FLT1	Cai et al (2012)47
Schizophrenia endophenotypes	NRG1	Savonenko et al (2008)46
Seizures	SCN2B	Kim et al (2007),51 Kobayashi et al (2008),40 Hu et al (2010),45 Hitt et al (2010)48
Spine density reduction	NRG1	Savonenko et al (2008)46
BACE2 knockout mouse phenotypes
Normal	..	Dominguez et al (2005)27
Pancreatic β-cell increase	TMEM27	Esterhazy et al (2009)52
Pigmentation abnormalities	PMEL	Rochin et al (2013)53
BACE1/2 knockout mouse phenotypes
Similar to BACE1 knockout, except postnatal lethality is enhanced	..	Dominguez et al (2005)27