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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Exp Neurol. 2014 Mar 30;256:25–38. doi: 10.1016/j.expneurol.2014.03.016

Fig. 1.

Fig. 1

CD36 deletion improves functional outcome after moderate spinal cord contusion. (A) Adult CD36−/− mice showed a significant improvement in locomotor recovery by day 21 in (n = 22, ****) relative to wildtype (n = 21, ****), as assessed by the BMS (*p < 0.05, **p < 0.01, ***p < 0.001). Data are means ± SEM. (B) Subscore analysis revealed a similar improvement in hindlimb coordination (*p < 0.05, **p < 0.01). Mean, ****; median, ****; outliers, *****; whiskers, 5th and 95th percentiles. Biophysical assessment of initial injury parameters showed no significant difference between groups with respect to IH impact displacement (C), the best predictor of injury severity (Ghasemlou et al., 2005), or force (D). (E) Deletion of CD36 significantly decreases contusion epicenter lesion area as defined by either (E) laminin or (F) GFAP deposition (WT, n = 4; CD36−/−, n = 4 per timepoint; ***p < 0.001). Data are means ± SEM. (G) Deletion of CD36 (n = 16, ****) increases the percentage of spare white matter relative to WT (n = 10, ****) caudal to and at the injury epicenter 7 weeks post-injury (*p < 0.05, **p < 0.01, ***p < 0.001). Negative values on the x-axis represent μm caudal to injury epicenter. Data are means ± SEM. Images (converted to monochrome) are representative epicenters of Eriochrome cyanine-stained coronal sections.