CD36−/− mice exhibit a reduced presence of heterodomain macrophages following SCI. The mean area within the injury heterodomain positive for the inflammatory markers Iba1 (pink, A, B, E) and CD16/CD32 (red, B, D, F) were significantly reduced by 7 dpi (**p < 0.01, *p < 0.05) in CD36−/− mice. GFAP and LEA are shown in blue and green, respectively (A–D). Data are means ± SEM (WT, n = 4; CD36−/−, n = 4 per timepoint). Bars = 500 μm.