Table 1.
Characteristics of included randomized controlled trials.
| First author, year (country) | Number of study sites | Sample size | Population, % | Mean age, (years) | Diabetic, % | Initial glucose, mg/dL | Glucose goal, mg/dL | Glucose achieved, mean (SD), mg/dL |
|---|---|---|---|---|---|---|---|---|
| Cappi 2012 (Brazil) [14] | 1 | 63 | Severe sepsis Septic shock |
53 | 24 | IIT 144 [97–182]∗ Control 141 [101–160]∗ | IIT 80–110 Control 140–180 |
IIT 99 (18) Control 155 (39.6) |
|
| ||||||||
| COIITSS 2010 (France) [16] | 11 | 509 | Septic shock 100 | 64 | NA | IIT 216 (NA) Control 204 (NA) | IIT 80–110 Control 180–200 |
IIT 120–140 Control 140–160 |
|
| ||||||||
| Savioli 2009 (Italy) [12] | 3 | 90 | Severe sepsis 65.6 Septic shock 34.4 |
61 | 13.3 | IIT 175 (101) Control 160 (74) | IIT 80–110 Control 180–200 |
IIT 112 (23) Control 159 (31) |
|
| ||||||||
| Iapichino 2008 (Italy) [11] | 3 | 72 | Severe sepsis 19.4 Septic shock 80.6 |
62.3 | 17 | IIT 137 (45) Control 151.7 (36.6) | IIT 80–110 Control 180–200 |
IIT 110 (17) Control 163 (29) |
|
| ||||||||
| Brunkhorst 2008 (Germany) [10] | 18 | 537 | Septic shock 100 | 64.6 | 30 | IIT 130 [108–167]∗ Control 138 [111–184]∗ | IIT 80–110 Control 180–200 |
IIT 112 (NA) Control 151 (NA) |
|
| ||||||||
| Ellger 2008 (Belgium) [25] | 1 | 950 | Severe sepsis 51.4 Septic shock 48.6 |
62 | 14 | IIT 163 (73) Control 161 (70) | IIT 80–110 Control 180–200 |
IIT 106 (26) Control 150 (30) |
|
| ||||||||
| Yu 2005 (China) [13] | 1 | 55 | Sepsis | 46 | NA | IIT 153 (61) Control 151 (65) | IIT 80–110 Control 180–200 |
IIT 103 (22) Control 198 (29) |
|
| ||||||||
| Dong 2009 (China) [27] | 1 | 27 | Septic shock 100 | 44 | 0 | IIT157 (45) Control 159 (39.6) | IIT 74–110 Control 112–150 |
IIT 108 (27) Control 148 (34) |
|
| ||||||||
| NICE-SUGAR 2009 (Australia and New Zealand—Canada) [17] | 42 | 1299 | Severe sepsis Septic shock |
60.2 | 20.1 | IIT 146 (52.3) Control 144 (49.1) | IIT 81–108 Control 180 or less |
IIT 115 (18) Control 144 (23) |
|
| ||||||||
| Arabi 2008 (Saudi Arabia) [24] | 1 | 122 | Severe sepsis Septic shock |
52.4 | 40.0 | IIT 195 (75) Control 211 (81) |
IIT 80–110 Control 180–200 |
IIT 115 (18) Control 171 (34) |
|
| ||||||||
| Zhang 2008 (China) [26] | 1 | 22 | Sepsis | 66.3 | 27.5 | IIT 165 (55) Control 200 (100) | IIT 80–110 Control 130–150 |
IIT 119 (7.6) Control 141 (7.9) |
|
| ||||||||
| Jin 2009# (China) [23] | 14 | 356 | Severe sepsis Septic shock |
65.7 | NA | IIT NA Control NA |
IIT 80–110; 120–150 Control 180–200 |
IIT 80–110: 99 (31); 120–150: 133 (34) Control 189 (40) |
IIT: intensive insulin therapy; NA: not available from article or author.
*Median (interquartile range).
#Abstract only.