FIG. 8.

Axonal damage and neuropathic pain in GSNOR-KO mice. (A) Representative Masson's Trichrome stained sections from sciatic nerve of wild-type (WT) (a, c) and GSNOR-KO (KO) (b, d) mice. (a, c) Section of wild-type mice sciatic nerve revealing high number of axons and thick myelin sheath. (b, d) Section of KO mice sciatic nerve showing a reduction of axons, regression of myelin, and clustered small myelinated fibers that are indicative of massive regeneration (arrowheads). (c, d) 2.5-fold magnification of (a, b), respectively Measurement of mechano-allodynia (B) and thermal hyperalgesia (C) of KO and WT mice. Results shown are the means±SEM of n=10 animals for each group, and the indicated p-value was calculated with regard to WT. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars