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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: J Neurochem. 2014 Apr 19;130(1):4–28. doi: 10.1111/jnc.12715

Fig. 3.

Fig. 3

Beta-site amyloid cleaving enzyme (BACE)1 controls peripheral nerve myelination and muscle spindle formation via proteolytic processing of neuregulin 1. (a) BACE1 deficiency results in hypomyelination of peripheral axons (left panel) and abnormalities in axonal-bundling (right panel) (Willem et al. 2006). (b) Delay of myelination in BACE1−/− zebrafish (van Bebber et al. 2013). At 3 days post-fertilization myelination of the posterior lateral line nerves (PNS) is severely reduced in BACE1−/−; claudin k: GFP (red arrows) whereas CNS derived oligodendrocytes ensheathing the Mauthner axons are normally myelinated (black arrows). (c) Proteolytic processing of neuregulin 1 (NRG1) type III by sheddases and intramembrane proteolysis.