. Author manuscript; available in PMC: 2014 Jul 8.

Published in final edited form as: J Neurochem. 2014 Apr 19;130(1):4–28. doi: 10.1111/jnc.12715

Table 1.

BACE1 null phenotypes in CNS

Phenotype	Substrate	References
Astrogenesis increase, neurogenesis decrease	Jag1	Hu et al. (2013)
Axon guidance defects	CHL1	Rajapaksha et al. (2011), Cao et al. (2012), Hitt et al. (2012)
Hyperactivity	NRG1	Dominguez et al. (2005), Savonenko et al. (2008)
Hypomyelination	NRG1	Willem et al. (2006), Hu et al. (2006, 2008)
Memory deficits	–	Ohno et al. (2006, 2007, 2004), Laird et al. (2005)
Neurochemical deficits	–	Harrison et al. (2003)
Neurodegeneration w/ age	Na_Vβ2	Hu et al. (2010)
Post-natal lethality, growth retardation	–	Dominguez et al. (2005)
Retinal pathology	VEGFR1	Cai et al. (2012)
Schizophrenia endophenotypes	NRG1	Savonenko et al. (2008)
Seizures	Na_Vβ2	Kim et al. (2007), Kobayashi et al. (2008), Hu et al. (2010), Hitt et al. (2010)
Spine density reduction	NRG1	Savonenko et al. (2008)