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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Arch Biochem Biophys. 2011 Dec 16;519(2):223–231. doi: 10.1016/j.abb.2011.10.023

Figure 4.

Figure 4

CAP-S62F-cAMP2 visits an active, low-populated conformational state. (A) Representative relaxation dispersion data of 15N backbone amides of CAP-S62F-cAMP2 DBD residues. (B) Backbone 15N chemical shift differences of the DBD residues between the apo and cAMP2-bound WT-CAP mapped on the structure. (C) Conformational exchange dynamics of CAP-S62F-cAMP2 on the μs – ms timescale as indicated by Rex, are mapped on the structure. (D) Plot of 15N static Δδ values (blue), Rex values (orange), and dynamic Δδ (green).

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