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. 2014 Jun 23;20(13-14):1908–1921. doi: 10.1089/ten.tea.2013.0188

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Copyright 2014, Mary Ann Liebert, Inc.

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FIG. 1. — Effects of soluble tenascin-C (TnC) and tenascin-R (TnR) in NBR-induced human mesenchymal stem cells (hMSCs). (A) The mRNA levels of neuron markers, MAP2 and NFM; (B) glial cell markers, GFAP and MBP; and (C) the synapse marker, synapsin (SYN) were quantified after 7 days of Tn treatment (0.5–1.0 μg/mL) in hMSCs that were pretreated with NBR for 1 week. Levels were normalized to levels observed in NBR-only treatment (set to 1.0) (presented as a dotted line). The NBR incorporated with the TnC and TnR mixture (TCR) promoted the expression of neuronal and glial cell genes, but not of synaptic genes. The data are presented as the mean±SD of an experiment that was derived from three independent experiments. *p<0.05, **p<0.01 (all vs. NBR). DMEM, Dulbecco's modified Eagle medium; GFAP, glial fibrillary acidic protein; MBP, myelin basic protein; NFM, neurofilament M; SD, standard deviation.