Table 4.
Projected number of individuals reaching ESRD and total accumulated QALYs, stratified by current CKD stage, for the base-case model population and a population with more severe disease (eg, diabetic nephropathy)
| KDIGO3 CKD category | Disease status | Urine albumin creatinine ratio (mg/g) | Serum albumin (g/dL) | Serum phosphate (mg/dL) | Serum bicarbonate (mEq/L) | Serum calcium (mg/dL) | # reaching ESRD per 1,000 subjects | QALYs per subject (undiscounted) |
|---|---|---|---|---|---|---|---|---|
| G3A | Base-case | 100 | 4.27 | 3.22 | 26 | 9.26 | 42 | 13.6 |
| More severe | 200 | 4.18 | 3.38 | 20 | 9.22 | 88 | 13.5 | |
| G3B | Base-case | 200 | 4.18 | 3.38 | 26 | 9.22 | 229 | 11.3 |
| More severe | 300 | 4.16 | 3.81 | 20 | 9.10 | 416 | 11.1 | |
| G4 | Base-case | 300 | 4.16 | 3.81 | 26 | 9.10 | 780 | 9.4 |
| More severe | 350 | 4.12 | 4.89 | 20 | 9.06 | 963 | 7.8 | |
| G5 | Base-case | 350 | 4.12 | 4.89 | 26 | 9.06 | 988 | 6.9 |
| More severe | 450 | 4.05 | 5.00 | 20 | 9.00 | 992 | 6.7 |
Abbreviations: ESRD, end-stage renal disease; CKD, chronic kidney disease; QALYs, quality-adjusted life-years; KDIGO, Kidney Diseases Improving Global Outcomes.