Table 1.
Baseline characteristics
| Demographic variable | ALS | N | Amnestic MCI | N | Healthy controls | N | p-value |
|---|---|---|---|---|---|---|---|
| Age at time of assessment |
60.4 (12.2) |
40 |
64.5 (5.4) |
39 |
62.7 (10.2) |
40 |
0.152 |
| Male sex |
65.0% (-) |
40 |
45.0% (-) |
39 |
69.2% (-) |
40 |
0.063 |
| Education (years)* |
13.0 (2.5) |
40 |
14.6 (2.8) |
37 |
14.0 (2.1) |
40 |
0.016 |
| BDI-II (estimated depression scores) |
7.9 (6.6) |
34 |
6.8 (4.7) |
35 |
4.7 (4.9) |
40 |
0.057 |
| ALSFRS-R |
38.4 (7.8) |
40 |
n.a. |
n.a. |
n.a. |
||
| Disease duration (in months; from symptom onset) |
22.16 (19.5) |
40 |
n.a. |
n.a. |
n.a. |
||
| Disease progression | 0.54 (0.36) | 40 | n.a. | n.a. | n.a. | ||
Values are mean (SD). Two-tailed p-values of <0.05 are considered significant, shown in bold.
ALS, amyotrophic lateral sclerosis; MCI, mild cognitive impairment; BDI-II, Beck Depression Inventory-II; ALSFRS-R, ALS Functional Rating Scale Revised; n.a., not applicable; disease duration, time from symptom onset to assessment; disease progression, estimated using decline in ALS Functional Rating Scale (ALSFRS-R) score since symptom onset (48-ALSFRS-R/disease duration [38]); *Years of education include: Years attended in school plus years of the longest, completed education.