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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Biol Psychiatry. 2011 Sep 1;71(3):232–238. doi: 10.1016/j.biopsych.2011.07.015

Figure 2.

Figure 2

Chronic ethanol increases the potency of certain delta opioid receptor (DOR)-selective agonists for thermal antinociception. Naïve C57BL/6 mice (n = 8–10) or mice (n = 8–9) that had chronically self-administered ethanol (see Methods and Materials) were injected intrathecally with increasing doses of a DOR-selective (deltorphin II [A], [D-Pen2,D-Pen5]-Enkephalin [B], SNC80 [C], or mu opioid receptor-selective (DAMGO [D]) agonist and thermal antinociception was measured using a radiant heat tail-flick assay. Data are represented as the percentage maximal possible effect, which is defined as [(measurement – baseline)/(cutoff – baseline)]*100. DPDPE, [D-Pen2,D-Pen5]-Enkephalin; MPE, maximal possible effect.