Table 1.

ED₅₀ Values (95% Confidence Interval, nmol) for Antinociception Produced by DOR-Selective and MOR-Selective Agonists in Naïve WT, DOR KO, and MOR KO Mice and WT Mice Who Had Been Voluntarily Consuming Ethanol

		ED₅₀ (95% CI, nmol)
	Mice	Deltorphin II	DPDPE	SNC80	DAMGO
Thermal	Naïve	1.19 (.9–1.6)	1.18 (.9–1.7)	ND	.009 (.006–.013)
	DOR KO	.75 (.5–1.1)^a	.69 (.3–1.5)	ND	.016 (.009–.031)
	MOR KO	ND	ND	ND	ND
	Ethanol	.42 (.31–.60)^b	.39 (.29–.55)^b	ND	.003 (.002–.007)
Mechanical	Naïve	1.66 (1.2–2.3)	6.37 (3.5–28.1)	5.04 (3.1–10.1)	.024 (.016–.039)
	DOR KO	ND	ND	ND	>.03
	MOR KO	ND	ND	6.06 (3.4–14.0)	>1
	Ethanol	2.06 (1.3–4.6)	8.61 (5.5–24.2)	4.06 (2.8–6.4)	.027 (.016–.046)

Thermal antinociception was measured using a radiant heat tail-flick assay. Mechanical sensitivity was measured using von Frey filaments. GraphPad Prism (Graphpad Software, La Jolla, California) was used to determine statistical differences between groups.

CI, confidence interval; DOR, delta opioid receptor; DPDPE, [D-Pen2,D-Pen5]-Enkephalin; ED₅₀, effective dose 50%; KO, knockout; MOR, mu opioid receptor; ND, not detectable; WT, wild-type.

p < .05.

p < .001.