Table 2.

List of some human 5-HT_2B receptor agonists and antagonists and their therapeutic indications.

5-HT2B Agents	Name	Structure	Mechanism of action	Therapeutic Indication
	Fenfluramine22		Increases Serotonin levels	Controls food intake or suppresses Obesity
	Norfenfluramine22		Metabolite of Fenfluramine. Increases Serotonin levels	Controls food intake or suppresses Obesity
	3,4-methylenedioxymeth amphetamine (MDMA, “Ecstasy”)25		Increases Serotonin levels	Posttraumatic stress disorder, Psychotherapy
	Alpha-methyl-5 -HT33		Increases Serotonin levels	Its prodrug alpha- methyltryptophan is used for treatment of disorders where serotonin is deficient
AGONISTS	Lysergic acid diethylamide (LSD)3		5-HT receptor agonist	Psychotherapy, Pain, Alcoholism etc.
	Carbergoline42		Dopamine agonist	hyperprolactinemia, Parkinson's disease etc.
	Dihydroergotamine42		Serotonin receptor agonist	Migraine treatment
	Methylergonovine42		Partial agonist/antagoni st on serotonergic, dopaminergic and alpha- adrenergic receptors	Control of postpartum hemorrhage & Migraines
	Pergolide42		Dopamine agonist	Parkinson’s Disease and Hyperprolactinemic Disorders
	Agomelatine3		MTi and MT2 agonist as well as 5-HT2C antagonist	Antidepressant
ANTAGONI STS	Asenapine3			Schizophrenia and mania associated with bipolar disorder
	Ketanserin3		alpha-1 adrenergic receptor antagonist	Antihypertensive
	Methysergide3		5-HT2B receptor agonist	Treatment of Migraines
	Ritanserin3		5HT2A/2C antagonist	Treatment of schizophrenia
	Tegaserod3		5-HT4 agonist	Management of irritable bowel syndrome and constipation
	Yohimbine3		Alpha-2 andrenergic receptor antagonist	Treatment of impotence or erectile dysfunction