Figure 4. Simulated results of intranuclear species abundance following an IR dose of 2.5 Gy at 0 h.

The time courses of phosphorylated p53, Mdm2, ATM-P, and Wip1 in four individual cells with zero (A), one (B), two (C), or three p53 pulses (D) are shown. Each species represents the summation of complexes including the species.