Table 3. Melanoma Risk of Genotypes Combining Indels and Rare Variants with Conventional MC1R Variants.
Genotype | Cases (n = 875) | Controls (n = 765) | Unadjusted OR (95% CI) | P-value |
Consensus/consensus | 163 | 216 | Ref | |
rare/consensus | 10 | 11 | 1.21 (0.50–2.91) | 0.68 |
Indel/consensus | 11 | 4 | 3.65 (1.14–11.65) | 0.03 |
rare/(R or r) | 15 | 3 | 6.63 (1.89–23.27) | <0.01 |
Indel/(r, R, or rare) | 11 | 2 | 7.29 (1.59–33.34) | 0.01 |
“R”: D84E, R151C, R160W, D294H.
“r”: V60L, V92M, R163Q, R142H, I155T.