Table 4. Melanoma Risk Based on MC1R Genotyping including Indels and Rare Variants.

Genotype	Cases (n = 875)	Controls (n = 765)	Unadjusted OR (95% CI)	P-value
Consensus/consensus	163	216	Ref
r/consensus	203	220	1.22 (0.93–1.62)	0.18
r/r	67	55	1.61 (1.07–2.43)	0.03
R/Consensus	208	172	1.60 (1.20–2.13)	<0.01
R/r	143	74	2.56 (1.81–3.62)	<0.01
R/R	91	28	4.31 (2.69–6.89)	<0.01

“R”: D84E, R151C, R160W, D294H, indels, rare variants.

“r”: V60L, V92M, R163Q, R142H, I155T.