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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Neurotoxicology. 2009 Jul 30;30(5):741–753. doi: 10.1016/j.neuro.2009.07.014

Fig. 1.

Fig. 1

Genotype-by-environment interactions. (A) Heterozygosity for the sickle cell anemia allele of hemoglobin (S/+) confers resistance to malaria. Homozygosity for wild-type hemoglobin (+/+) confers susceptibility to infection by Plasmodium, and this leads to increased mortality. (B) Drosophila genes with GxE-eQTL have similar expression levels in the absence of lead (−Pb), but have a decrease in expression in the presence of lead (+Pb) in one genotype but not the other. Shown is repression by lead when the genotype is ORE but not 2B.